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European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Genetics Antibodies Age of Onset Rheumatoid Arthritis Patient POLYMORPHISM Association study Anti-citrullinated protein antibodies CASP7 GENE Anti-Idiotypic Young Adult Reproducibility Protein Tyrosine Phosphatase Antirheumatic Agents Biologie computationnelle des systèmes Epitopes France Computational systems biology Algeria HLA-DRB1 Autoimmune thyroid diseases 80 and over Family Health Polyarthrite rhumatoïde Europe Male Biocuration Humans Adolescent Aged Ankylosing APOPTOSIS Genotype Biological pathway Phenotype HLA-DR Antigens Logical modelling Genetic Association Studies Arthritis ASSOCIATION STUDY Female Receptors Genetic Linkage Gene Frequency Biomarkers Genetic Predisposition to Disease CARD Signaling Adaptor Proteins Cohort Studies African Continental Ancestry Group ATP Binding Cassette Transporter Antigens Autoantibodies Linkage Disequilibrium Tunisia Rheumatoid arthritis Haplotypes Autoimmune Diseases European Continental Ancestry Group Adult Odds Ratio Autoantibody Production Boolean simulations Rheumatoid Arthritis Binding Sites Autoimmune thyroid disease Single Nucleotide Genetic Shared Epitope Systems biology Complex genetic disease Autoimmunity Polymorphism Ankylosing spondylitis Middle Aged Network inference PTPN22 gene Analysis Boolean models Annotation standards Rheumatoid Factor Algerian population Animals Case-Control Studies Age Factors HLA-DRB1 Chains Boolean networks Génétique Environment Disease maps Antigen Presentation ABCB1 Non-Receptor Type 22 Family Databases C-Type Alleles Biologie des systèmes Rheumatoid RHEUMATOID ARTHRITIS Risk Factors In silico simulations

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